Adverse effects identified in pregnant women with a history of gestational diabetes
Early intervention may be required for pregnant women with a history of gestational diabetes mellitus (GDM) to offset adverse effects.
A study by researchers from Beijing Obstetrics and Gynecology Hospital looked at the clinical characteristics, gestational weight gain and pregnancy outcomes in women with GDM history, and found that women with prior GDM have glucose and lipid metabolism disorders in their 1st trimester.
The retrospective study examined the results for 441 pregnant women with prior GDM compared to 1,637 women without a history of GDM.
Published in the Diabetology & Metabolic Syndrome, the results show that: “Among women with GDM history, triglycerides (TG) and fasting plasma glucose (FPG) in the 1st trimester were higher than those without GDM history. GWG was lower in women with prior GDM relative to the control group at various pregnancy stages.
“However, women with GDM history had a higher risk of developing GDM (OR 3.25, 95% CI 2.26–4.68) and pregnancy-induced hypertension (OR 1.50, 95% CI 1.05–2.45). In women with previous GDM, excessive GWG before oral glucose tolerance test (OGTT) exhibited a positive correlation with pregnancy-induced hypertension (OR 1.47, 95% CI 1.05–3.32), while inadequate GWG was not a protective factor for GDM and pregnancy-induced hypertension.”
The report concludes that “limited reduction of GWG before oral glucose tolerance test (OGTT) was insufficient to offset the adverse effects of glucose and lipid metabolism disorders in women with previous GDM. Relevant interventions may be required at early stage or even before pregnancy.”
Click here to read the study by Xin Liang, Wei Zheng, Cheng Liu, Lirui Zhang, Li Zhang, Zhihong Tian and Guanghui Li.