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Artificial pancreas ‘safe and effective’ for type 1 diabetes

By Editor
20th April 2018

The artificial pancreas systems is a “safe and effective” treatment  for people with type 1 diabetes, a study published by The BMJ has concluded.

A review of the available evidence has concluded that the use of artificial pancreas was associated with better control of blood sugar levels for people with type 1 diabetes compared with standard treatment.

The findings show that artificial pancreas treatment provides almost two and a half extra hours of normal blood glucose levels (normoglycaemia) a day, while reducing time in both high (hyperglycaemia) and low (hypoglycaemia) blood glucose levels.

The researchers from Greece’s Aristotle University of Thessaloniki said the results support the view that “artificial pancreas systems are a safe and effective treatment approach for people with type 1 diabetes”, but added that further research was needed to verify the findings.

The artificial pancreas is a system that measures blood sugar levels using a continuous glucose monitor (CGM) and transmits this information to an insulin pump that calculates and releases the required amount of insulin into the body, just as the pancreas does in people without diabetes.

Lead researcher Eleni Bekiari reviewed the results of 41 randomised controlled trials involving over 1000 people with type 1 diabetes, that compared artificial pancreas systems with other types of insulin based treatment, including insulin pump therapy.

They found that the artificial pancreas was associated with almost two and a half additional hours in normoglycaemia compared with other types of treatment when used overnight and over a 24-hour period.

Use of the artificial pancreas also reduced time spent in hyperglycaemia by approximately two hours – and in hypoglycaemia (20 minutes less) – compared to other therapies.

Further analyses to test the strength of the associations for different devices and in different settings were consistent, suggesting that the results are robust.

The researchers said that the review provided  a valid and up to date overview on the use of artificial pancreas systems for type 1 diabetes. However, they point out that most trials were at high or unclear risk of bias, had a small sample size and short duration, and therefore should be interpreted with caution.

Furthermore, they suggest more should be done to assess cost-effectiveness “to support adoption of artificial pancreas systems in clinical practice.”

The authors also recommend that future research should “explore artificial pancreas use in relevant groups of people with type 2 diabetes” and say “the effect of artificial pancreas use on quality of life and on reducing patient burden should be further explored.”

Professor Norman Waugh, from the University of Warwick, and colleagues, argued in a linked editorial that closed loop systems have much to offer, but added “we need better evidence to convince policymakers faced with increasing demands and scarce resources”.

To access the study, click here.

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