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Medication intensification linked to improved glyceamic control

By Editor
31st August 2018

Earlier treatment intensification is associated with shorter time to subsequent glyceamic control, according to a study.

The research team say the findings are irrespective of whether people with type 2 diabetes initiate first-line treatment with metformin or a sulfonylurea.

The trial was carried out to evaluate the association between the timing of treatment intensification and subsequent glycemic control among patients with type 2 diabetes in whom monotherapy fails.

It involved 93,515 people who met the study criteria (mean age 60 years; ∼59% male; 80% taking metformin), 23,761 (25%) intensified <12 months after the index date; 11,908 (13%) intensified after 12 to <24 months; and 7,146 (8%) intensified after 24 to <36 months.

Those who intensified treatment ≥36 months after the index date (n = 9,638 [10%]) and those with no evidence of treatment intensification during the observable follow-up period (n = 41,062 [44%]) were not included in further analyses.

The median times from intensification to control were 20.0, 24.1, and 25.7 months, respectively, for the early, intermediate, and late intensification cohorts.

After adjustment for baseline differences, the likelihood of attaining glycemic control was 22% and 28% lower for patients in the intermediate and late intensification groups, respectively, compared with those intensifying early (P < 0.0001).

To read the study, click here.

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