One-hour glucose improves type 2 diabetes prediction
The one-hour glucose level during an oral glucose-tolerance test (OGTT) improves the early prediction of type 2 diabetes, according to a new study.
In the Botnia Prospective Study, the team assessed the performance of plasma glucose levels measured at different time points during the OGTT, HbA1c, metabolic markers and clinical risk factors, and combinations thereof, for predicting type 2 diabetes.
Altogether, they evaluated 1,527 predictive models which included various combinations of these variables.
Speaking to Reuters Health, Dr Gopal Peddinti from the VTT Technical Research Center of Finland said: “It was interesting that 1-hour plasma glucose (PG) alone was almost as good as most other multivariate models, in particular the combination of HbA1c and 1-hour PG, in predicting type 2 diabetes.
“At the same time, it is interesting that metabolites significantly improve our ability to predict T2D beyond commonly used clinical predictors (including OGTT-derived glucose levels).”he told Reuters Health by email.
Previous studies have identified a number of metabolic biomarkers that are associated with the incidence of prediabetes and type 2 diabetes. Dr Peddinti and colleagues earlier identified seven metabolic markers that provided the best predictive model in combination with clinical risk factors.
Among the plasma glucose measurements, the one-hour plasma glucose showed the best predictive performance for type 2 diabetes, with 75% sensitivity, 68% specificity and 75% accuracy (by AUC), followed by the 30-minute plasma glucose, with 62% sensitivity, 71% specificity and 71% accuracy.
Both measures were more accurate than fasting plasma glucose or two-hour plasma glucose.
To read the study, click here.