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Prandial insulin study findings unveiled

By Editor
3rd July 2018

The Pankowska Equation resulted in reduced postprandial hyperglycaemia at the expense of an increase in hypoglycaemia in a recent study.

A randomised, crossover trial at that took place at two paediatric diabetes centres compared two novel insulin‐dosing algorithms (the Pankowska Equation and the Food Insulin Index) with carbohydrate counting on postprandial glucose excursions following a high fat and a high protein meal.

The researchers also found there were no significant differences when carbohydrate counting was compared to the Food Insulin Index, although research into the subject is required.

The research involved 33 children how on each day were asked to consume a high protein or high fat meal with similar carbohydrate amounts. Insulin was delivered according to carbohydrate counting, the Pankowska Equation or the Food Insulin Index. Subjects fasted for five hours following the test meal and physical activity was standardised. Postprandial glycaemia was measured for 300 min using continuous glucose monitoring.

When compared to carbohydrate counting, the Pankowska Equation resulted in lower glycaemic excursion for 90–240 min after the high protein meal (p < 0.05) and lower peak glycaemic excursion (p < 0.05).

The risk of hypoglycaemia was significantly lower for carbohydrate counting and the Food Insulin Index compared to the Pankowska Equation (OR 0.76 carbohydrate counting vs. the Pankowska Equation and 0.81 the Food Insulin Index vs. the Pankowska Equation).

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