ABCD COVID-19 and type 1 diabetes audit results published
A higher BMI, poorer renal function and microvascular complications can lead to more severe COVID-19 symptoms in those admitted to hospital with the virus who have type 1 diabetes.
That is according to the findings of a UK-wide study of people with type 1 diabetes admitted to hospital with COVID-19 infection led by the Association of British Clinical Diabetologists (ABCD).
According to the results, risk of severe coronavirus was “reassuringly very low in people with type 1 diabetes who are under 55 years of age without microvascular or macrovascular disease”.
A total of 40 centres submitted data to the audit, which took place between March to October 2020 and aimed to describe the clinical characteristics of adults with type 1 diabetes admitted to hospital and the risk factors associated with severe coronavirus disease. The final dataset included 196 adults.
Summarising the results, the researchers said: “The prevalence of pre-existing microvascular disease and macrovascular disease was 56% and 39%, respectively. The prevalence of diabetic ketoacidosis on admission was 29%. A total of 68 patients (35%) died or were admitted to AICU. The proportions of people that died were 7%, 38% and 38% of those aged <55, 55–74 and ≥75 years, respectively. BMI, serum creatinine levels and having one or more microvascular complications were positively associated with the primary outcome after adjusting for age.
They concluded: “In people with type 1 diabetes and COVID-19 who were admitted to hospital in the UK, higher BMI, poorer renal function and presence of microvascular complications were associated with greater risk of death and/or admission to AICU. Risk of severe COVID-19 is reassuringly very low in people with type 1 diabetes who are under 55 years of age without microvascular or macrovascular disease.”